Avueprep is a water soluble Ethylenediaminetetraaceticacid (EDTA) gel for root canal cleaning.

Avueprep works by reacting with the mineral components of the hard tissues of the tooth. The chelating agent Avueprep softens the tissues, decalcifying the canal walls. It facilitates the mechanical preparation of the root canal and further removal of the smear layer, which opens dentin tubules

EDTA is a polyaminocarboxylic acid and a colorless, water-soluble solid. It is widely used to dissolve lime scale. Its usefulness arises because of its role as a hexadentate ligand and chelating agent, i.e. its ability to sequester metal ions such as Ca²⁺ and Fe³⁺.

Indications of Avueprep EDTA with carbamide peroxide:

• Chelating (calcium binding) agent react with minerlized component of tooth.
• Removal of the smear layer which is produced during instrumentation.
• For chemical and mechanical cleaning of the root canal.
• Shaping of the root canal via using rotary or hand files.
• To be used with sodium hypochlorite as carbamide peroxide helps to produce nascent oxygen molecules when used with sodium hypochlorite

Smear layer removal :

The use of 15% -17%EDTA resulted in the greatest concentration of calcium ions compared with other chelating agents. Avueprep/Avueprep+ were the most efficient solution for removal of smear layer.

Antimicrobial activity

The antibacterial activity of Avueprep is due to the chelation of cations from the outer membrane of bacteria.

Effects on Dentin microhardness:

it reduce the root dentine microhardness, whereby the greatest differences are to be found in dentine immediately adjacent to the root canal lumen. After 3 min, Avueprep produced a greater reduction in microhardness.

Positively affect adhesion of root canal sealer:

Treating dentine with a combination of NaOCl and  EDTA produced stronger adhesion of resin based sealer compared to NaOCl alone.

Avueprep is Biocompatible

It has been proven that even if EDTA is forced through the apical foramen into the periapical tissues, no periapical tissue damage could be detected after 14 months. Furthermore, that placement of EDTA for 28 days after pulpotomy produced no pulpal tissue necrosis. However, changes in macrophage activity can cause the inflammatory reaction to be more easily initiated, but reduced capacity of phagocytosis can result. Furthermore, EDTA improves plasma extravasation and mediator action. 

Can remove calcium hydroxide while using Avueprep

It has been revealed that using Avueprep or NaOCl alone as irrigants did not remove calcium hydroxide from the root canal, but combining these two irrigants with hand instrumentation improved the effectiveness of the removal.

Composition of Avueprep

EDTA Disodium Salt – 15% w/w
Carbamide Peroxide – 10% w/w
Lubricants and Excipients