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Local anesthetics reversibly block nerve transmission, when applied to a limited area of the body. They bind to the sodium channels in the nerve membrane and prevent the entry of sodium ions in response to the membrane’s depolarization. A vasoconstrictor like Adrenaline added to a local anesthetic may significantly prolong the anesthetic’s duration of action by reducing the blood flow around the injection site. This in turn may reduce the local anaesthetic’s peak plasma concentration and the risk of adverse systemic reactions.
